Priones
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Taxonavigation
editImperium: Biota
Superdomain: Acytota
Domain: Aminoacuea
Divisio: Priones
Overview of subtaxa
editMammalian prions
edit| ICTVdb Code | Disease name | Natural host | Prion name | PrP isoform |
|---|---|---|---|---|
| Non-human Mammalia | ||||
| 90.001.0.01.001. | Scrapie | Caprinae spec. | Scrapie prion | OvPrPSc |
| 90.001.0.01.002. | Transmissible mink encephalopathy (TME) | Neovison | TME prion | MkPrPSc |
| 90.001.0.01.003. | Chronic wasting disease (CWD) | Cervus spec. | CWD prion | MDePrPSc |
| 90.001.0.01.004. | Bovine spongiform encephalopathy (BSE) | Bovinae spec. | BSE prion | BovPrPSc |
| 90.001.0.01.005. | Feline spongiform encephalopathy (FSE) | Felinae spec. | FSE prion | FePrPSc |
| 90.001.0.01.006. | Exotic ungulate encephalopathy (EUE) | Tragelaphus spec. | EUE prion | NyaPrPSc |
| Human diseases | ||||
| 90.001.0.01.007. | Kuru disease | Hominina | Kuru prion | HuPrPSc |
| 90.001.0.01.008. | Creutzfeldt-Jakob disease (CJD) | CJD prion | ||
| (New) Variant Creutzfeldt-Jakob disease (vCJD, nvCJD) | vCJD prion[1] | |||
| 90.001.0.01.009. | Gerstmann-Sträussler-Scheinker syndrome (GSS) | GSS prion | ||
| 90.001.0.01.010. | Fatal familial insomnia (FFI) | FFI prion | ||
Fungal prions
edit| Protein | Natural Host | Normal Function | Prion State | Prion Phenotype | Year Identified |
|---|---|---|---|---|---|
| Ure2p | Saccharomyces cerevisiae | Nitrogen catabolite repressor | [URE3] | Growth on poor nitrogen sources | 1994 |
| Sup35p | Saccharomyces cerevisiae | Translation termination factor | [PSI+] | Increased levels of nonsense suppression | 1994 |
| HET-S | Podospora anserina | Regulates heterokaryon incompatibility | [Het-s] | Heterokaryon formation between incompatible strains | 1997 |
| vacuolar protease B | Saccharomyces cerevisiae | death in stationary phase, failure in meiosis | [β] | failure to degrade cellular proteins under N starvation | 2003 |
| MAP kinases | Podospora anserina | increased pigment, slow growth | [C] | 2006 | |
| Rnq1p | Saccharomyces cerevisiae | Protein template factor | [RNQ+],[PIN+] | Promotes aggregation of other prions | 2008 |
| Mca1 | Saccharomyces cerevisiae | Putative Yeast Caspase | [MCA+] | Unknown | 2008 |
| Swi1 | Saccharomyces cerevisiae | Chromatin remodeling | [SWI+] | Poor growth on some carbon sources | 2008 |
| Cyc8 | Saccharomyces cerevisiae | Transcriptional repressor | [OCT+] | Transcriptional derepression of multiple genes | 2009 |
| Mot3 | Saccharomyces cerevisiae | Nuclear transcription factor | [MOT3+] | Transcriptional derepression of anaerobic genes | 2009 |
| Pma1+Std1 [2] | Saccharomyces cerevisiae | Pma1 = major plasma membrane proton pump, Std1=minor pump | [GAR+] | Resistant to glucose-associated repression | 2009 |
| Sfp1 [3] | Saccharomyces cerevisiae | Global transcriptional regulator | [ISP+] | Antisuppressor of certain sup35 mutations | 2010 |
| Mod5 [4] | Saccharomyces cerevisiae | [MOD+] | 2012 |
References
edit- ↑ Believed to be identical to the BSE prion.
- ↑ Brown JC, Lindquist S 2009. A heritable switch in carbon source utilization driven by an unusual yeast prion. Genes Dev, 23(19): 2320–32. doi:10.1101/gad.1839109. PMC 2758746. PMID 19797769.
- ↑ Rogoza T, Goginashvili A, Rodionova S, Ivanov M, Viktorovskaya O, Rubel A, Volkov K, Mironova L 2010. Non-Mendelian determinant [ISP+] in yeast is a nuclear-residing prion form of the global transcriptional regulator Sfp1. Proc Natl Acad Sci U S A, 107(23): 10573–7. doi:10.1073/pnas.1005949107. PMC 2890785. PMID 20498075.
- ↑ Suzuki G, Shimazu N, Tanaka M 2012. A Yeast Prion, Mod5, Promotes Acquired Drug Resistance and Cell Survival Under Environmental Stress. Science, 336(6079): 355–359. doi:10.1126/science.1219491. PMID 22517861.
Links
edit- Zicha, Ondřej et al. Priones – Taxon details on Biological Library (BioLib).
- ICTV 9th report 2011
Alternative classification
editClassification System: ICTV (2023 Release, MSL#39, release v3)
(Unranked): Virus
Group: Prions