The genus name Acantholoma may refer to:

  • Plantae:
    • Acantholoma Gaudich. ex Baill. (1865) = synonym of Pachystroma Müll.Arg. (Malpighiales, Euphorbiaceae)
    • Acantholoma Herzog (1926), nom. illeg. = replaced by Bryoacantholoma W.Schultze-Motel = synonym of Spiridens Nees (Bryophyta, Spiridentaceae)